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Antiatherosclerotic effect of Bunapi

Hitoshi Ishida, Graduate School of Pharmaceutical Sciences, University of Shizuoka
Masahiko Ikeda, Graduate School of Health Sciences, University of Shizuoka
Mushroom laboratory, HOKUTO Corporation

 Antiatherogenic effects of Eryngii, Maitake, and Bunapi were examined in atherosclerosis-susceptible C57BL/6J, apolipoprotein E-deficient mice. Male apolipoprotein E-deficient mice (6 weeks of age) were fed normal diet or normal diet containing 3 % dried mushroom powder of Eryngii, Maitake or Bunapi for 10 weeks. Food intake, body weight, serum total cholesterol and triglyceride were measured periodically during the experimental period. At the end of the experiment (16 weeks of age), the size of atherosclerotic lesions of cross-sections from aortic root was measured. Body weight and food intake did not differ significantly among the groups through the experiment period. Serum total cholesterol concentration in the Eryngii, Maitake and Bunapi group were significantly lower than Control group, and were reduced by 19.5 %, 16.1 %, and 28.9 % compared with the Control group at the 16 weeks of age. However there was no significant difference in serum triglyceride concentration among the groups. The atherosclerotic lesions at 16 weeks of age in the three mushroom groups were significant lower than control group and were 53.0 %, 55.1 % and 26.4 % of the Control group respectively. In conclusion, it was revealed that Eryngii, Maitake and Bunapi have cholesterol lowering and antiatherogenic effect. The effects of Bunapi were especially stronger than Eryngii and Maitake.

Total cholesterol
Data are expressed as mean±SD, n=5.

Atherosclerotic lesion

Cross-sections of aortic sinus from apolipoprotein E-deficient mice at 16 weeks of age


Area painted with green ; atherosclerotic lesion

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